Pre-existing intimal hyperplasia and expression of NF-κB and VCAM-1 in great saphenous veins in patients with coronary artery disease and diabetes mellitus
10.3760/cma.j.issn.1001-4497.2014.07.007
- VernacularTitle:合并糖尿病的冠状动脉粥样硬化性心脏病患者大隐静脉内膜增生及NF-κB、VCAM-1表达的研究
- Author:
Wenqi LUO
;
Wenjun ZHEN
;
Huaibin WANG
;
Jie TAN
;
Yujian MA
- Publication Type:Journal Article
- Keywords:
Coronary artery bypass grafting;
Diabetes mellitus;
Great saphenous vein;
Intimal hyperplasia
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2014;30(7):408-410,414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pre-existing intimal hyperplasia and the expression of nuclear factor-κB (NF-κB) and vascular cell adhesion molecule 1 (VCAM-1) in great saphenous vein(GSV) among the patients with diabetes mellitus undergoing coronary artery bypass grafting(CABG).Methods Segments of GSV were collected from 20 patients with diabetes mellitus and 22 patients without diabetes mellitus undergoing CABG.Morphometric analysis was performed after hematoxylin-eosin (HE) staining and Masson staining by microscopic computer analysis.Immunohistochemistry staining was used to examine the expression of NF-κB and VCAM-1 in intima.Results Pre-existing intimal hyperplasia was more common and server in GSV of the patients with diabetes mellitus.The expression of NF-κB and VCAM-1 were significantly higher in intima of GSV in patients with diabetes mellitus than patients without diabetes mellitus.The expression of VCAM-1 was positively related to NFκB in intima of GSV.Conclusion The pre-existing intimal hyperplasia and the expression of NF-κB and VCAM-1 were more common and server in GSV of the patients with diabetes mellitus than patients without diabetes mellitus.This can partially explain the poor prognosis of patients with diabetes mellitus after CABG.
