The changes of pulmonary surfactant associated protein of sputum and oxygenation index in dysfunctional ventilatory weaning response patients
10.3969/j.issn.1671-8348.2014.20.010
- VernacularTitle:呼吸机依赖患者痰液中SP-A与动脉血氧合指数变化的研究
- Author:
Yangjia DENG
;
Qian WU
;
Yuhong WEI
;
Lei DU
;
Lian FU
- Publication Type:Journal Article
- Keywords:
pulmonary surfactant-associated protein A;
blood gas analysis;
ventilator dependence
- From:
Chongqing Medicine
2014;(20):2572-2573,2576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of SP-A in surface active substance of sputum pulmonary of dysfunctional venti-latory weaning response patients and to study changes of expression of SP-A and oxygenation index ,arterial partial pressure of oxy-gen .Methods The mechanical ventilatory patients were divide into dysfunctional ventilatory weaning response group (group A) and easily weaning group(group B) ,then collected sputum from ventilators at different times :on the first day ,two and seven days after using ventilators .Used ELISA to test level of SP-A and oxygenation index ,arterial partial pressure of oxygen in sputum of group A and group B .Results For group A ,SP-A content oxygenation index and arterial partial pressure of oxygen were significantly less than those for group B(P<0 .05);after two days ,for group A ,SP-A content in sputum was significantly less than that on the first day ,and SP-A content in sputum was significantly less than that on the second day (P<0 .05);two days later ,oxygenation index and arterial partial pressure of oxygen were significantly lmore than those on the first day (P<0 .05) and there was no statistical difference in oxygenation index and arterial partial pressure of oxygen between the seventh day and the second day (P>0 .05) .Con-clusion Dysfunctional ventilatory weaning response and lung injury related to ventilator can be diagnosed early through the test of SP-A content in sputum ,which provides a brand-new way and method of treatment in dysfunctional ventilatory weaning response and lung injury related to ventilator .
