The curative effect and safety research of bisoprolol in the treament of the elderly COPD patients with chronic heart failure
10.3969/j.issn.1671-8348.2014.20.012
- VernacularTitle:比索洛尔治疗高龄COPD 合并CHF患者的疗效及安全性研究
- Author:
Qian LIU
;
Li CHENG
;
Hua LI
;
Dan GAN
;
Yong CHEN
;
Ji ZHANG
- Publication Type:Journal Article
- Keywords:
aged;
chronic obstructive pulmonary disease;
chronic heart failure;
bisoprolol
- From:
Chongqing Medicine
2014;(20):2577-2578,2581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the curative effect and security of bisoprolol in the elderly chronic obstructive pulmonary disease (COPD) patients combined with chronic heart failure (CHF) .Methods 61 cases of elderly COPD patients combined with CHF in our hospital were selected .on the basis of conventional treatment ,the patients were applicated bisoprolol 2 .5 mg ,1 time each day , the NT-proBNP ,LVEF% ,LEVDD and FEV1% were respectively observed before treatment ,4 weeks after treatment ,8 weeks af-ter treatment ,6 months after treatment .Results 4 weeks after treatment ,NT-proBNP ,LVEF% ,LEVDD showed no significant changes .8 weeks after treatment ,NT-proBNP and LEVDD decreased(P<0 .05) ,LVEF% showed no significant changes .6 months after treatment ,NT-proBNP and LEVDD decreased significantly ,meanwhile LVEF% increased (P< 0 .05) .before treatment ,4 weeks after treatment ,8 weeks after treatment ,6 months after treatment ,FEV1% were 47 .33 ± 5 .57 ,47 .08 ± 5 .50 ,48 .30 ± 6 .31 , 49 .64 ± 6 .24 ,All groups showed no changes in the pulmonary function(P>0 .05) .NT-proBNP of all groups were negatively corre-lation with the FEV1% (r= -0 .708 ,-0 .702 ,-0 .833 ,-0 .778) .Conclusion Small doses of bisoprolol is safe and effective in the treament of the elderly COPD patients with chronic heart failure .
