Change of soluble P-selectin and von Willebrand factor levels in traumatic patients
10.3969/j.issn.1673-4130.2014.14.008
- VernacularTitle:创伤患者可溶性P选择素与血管性血友病因子的水平变化
- Author:
Yingying PAN
;
Yingying CHEN
;
Biyu ZHANG
;
Ning TANG
- Publication Type:Journal Article
- Keywords:
intensive care unit;
soluble P-selectin;
von Willebrand factor
- From:
International Journal of Laboratory Medicine
2014;(14):1833-1835,1838
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of soluble P-selectin (sPsel)and von Willebrand factor (vWF)levels after ad-mission in traumatic patients and their relation with the coagulation indexes levels,coagulation disorders and prognosis.Methods 82 cases of severe trauma in ICU of Affiliated Tongji Hospital were prospectively selected and detected plasma sPsel,VWF anti-gen,protein C,activity of coagulation factor Ⅶ and routine coagulation indexes on admission and on every day within the first week after admission.The 30 d fatality rate was recorded.Results The sPsel and vWF levels on admission in the patients with coagula-tion disorders were lower than those in the patients without coagulation disorders (P <0.05)and significantly correlated with the coagulation indexes (protein C and coagulation factor Ⅶ)levels (P <0.05).The vWF level within 3 d after admission in the death patients was significantly lower than that in the survival patients,but which on 7 d after admission in the death patients was signifi-cantly higher than that in the survival patients (P <0.05 );no significant difference in sPsel level within 1 week after admission were found between the survival patients and the death patients.Conclusion Among severe traumatic patients in ICU,the low lev-els of sPsel and VWF on admission are associated with the coagulation disorders,the significant rise of vWF level on 7 d after ad-mission is associated with the increase of the 30 d fatality rate.
