Prediction value of IL-28B gene polymorphism on antiviral curative effect in patients with chronic hepatitis B
10.3969/j.issn.1673-4130.2014.14.022
- VernacularTitle:IL-28B 基因多态性对慢性 HBV 患者抗病毒治疗疗效的预测价值
- Author:
Xiaofeng HU
;
Jianjie CHEN
;
Minfang ZHU
;
Liping MING
- Publication Type:Journal Article
- Keywords:
IL-28B;
chronic hepatitis B;
PEG-IFN;
curative prediction
- From:
International Journal of Laboratory Medicine
2014;(14):1868-1869,1872
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of IL-28B gene on the antiviral curative effect in the patients with chronic hepatitis B.Methods 205 HBeAg-positive patients treated with the antiviral therapy of pegylation interferon(PEG-IFN)were detected the IL-28B rs12980275 and rs12979860 genotypes by TapManSNP genotyping assay and the relationship between the IL-28B genotypes and HbeAg seroconversion at end of treatment was analyzed.Results Among 205 cases,6 cases of genotype were uncertainty,the frequencies of IL-28B genotypes in other 199 cases were 77%,19%,5% for AA,AG,GG genotypes at rs12980275 and 76%,20%, 4%,for CC/CT/TT genotypes at rs12979860 respectively.The IL-28B polymorphisms were significantly correlated with the HbeAg seroconversion at the end of PEG-IFN treatment (P =0.001).In rs12979860 genotype,by the HBV genotyp,age,HBV lev-el,ALT and the combined therapy,the odds ratio (OR)of AA versus AG/GG was adjusted to 3.16 by HbeAg seroconversion.The similar result also obtained for the rs12980275 genotype.The IL-28B genotype was also associated with the HBsAg clearance.Con-clusion The IL-28B gene polymorphism is associated with the antiviral curative effect in the patients with HBeAg positive chronic hepatitis B.
