Relationship between abdominal microenvironment with abdominal cavity metastasis of epithelial ovarian cancer
10.3969/j.issn.1673-4130.2014.14.027
- VernacularTitle:腹腔微环境与卵巢上皮性癌腹腔转移关系的研究
- Author:
Kaiwen TANG
- Publication Type:Journal Article
- Keywords:
enterocoelia;
epithelial ovarian cancer;
metastasis
- From:
International Journal of Laboratory Medicine
2014;(14):1880-1881,1884
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between the abdominal microenvironment with abdominal cavity metastasis of epithelial ovarian cancer.Methods In order to reveal the mechanism of chemokines mediating epithelial ovarian cancer abdominal cavity metastasis,the expressions of chemokine receptor and its ligand in the epithelial ovarian carcinoma tissue and the peritoneal tissue were detected by RT-PCR and immunohistochemical.Results The expression of chemokine receptor CXCR4 in the epithelial ovarian carcinoma tissue was significantly higher than that of other chemokine receptors (P <0.01).The CXCR4 ligand SDF-1 was high-expressed in the epithelial ovarian carcinoma tissue and the peritoneal tissue.Conclusion The CXCR4 and SDF-1 are high-ex-pressed in the ovarian cancer tissue and may stimulate the excessive growth of ovarian cancer cells by the autocrine function;SDF-1 in the peritoneal tissue is high-expressed and may mediate the ovarian cancer cells expressing CXCR4 transferred to the abdominal cavity.
