Study on the relationship between matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 and ;missed abortion
10.3760/cma.j.issn.1008-6706.2013.s2.003
- VernacularTitle:基质金属蛋白酶-9、基质金属蛋白酶组织抑制物-1与稽留流产的相关性研究
- Author:
Jin XIE
;
Qiaoling LIU
- Publication Type:Journal Article
- Keywords:
Abortion,missed;
Matrix metalloproteinases
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(z2):7-8,9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the differential expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitors of metalloproteinase-1(TIMP-1) in serum and decidua tissue from missed abortion and normal first trimester pregnancy,and to explore their function in early pregnancy .Methods The expression of MMP-9,TIMP-1 in serum was determined using enzyme-linked immunosorbent assay ( ELISA) ,and in decidua by immunohistochemical method . Results The MMP-9 serum level from missed abortion women was higher than that from normal first trimester preg -nancy women [(154.60 ±28.69)ng/mL vs.(135.75 ±18.35)ng/mL,t=3.50,P=0.001].The TIMP-1 serum level from missed abortion women was lower than that from normal first trimester pregnancy women [(253.03 ± 29.90)ng/mL vs.(323.15 ±33.62) ng/mL,t=9.86,P=0.000].The MMP-9 positive expression rate in decidua tissue was higher in missed abortion women than that in normal first trimester pregnancy women (82.5%vs.42.5%,χ2 =13.65,P=0.000).The TIMP-1 positive expression rate in decidua tissue was lower in missed abortion women than that in normal first trimester pregnancy women (87.5%vs.62.5%,χ2 =6.67,P=0.010).Conclusion The expression of MMP-9 and TIMP-1 in serum and decidua may be assosiated with missed abortion .
