Expressions and clinical significances of SMO, STAT3 and MMP-9 in triple negative breast cancer
10.3969/j.issn.1000-484X.2014.06.022
- VernacularTitle:Smoothened、STAT3和MMP-9在三阴性乳腺癌中的表达及临床意义
- Author:
Ming FANG
;
Le KANG
;
Yingjie CHEN
;
Jian LIU
;
Junyan MA
;
Yajun TAO
- Publication Type:Journal Article
- Keywords:
TNBC;
Smoothened;
STAT3;
MMP-9
- From:
Chinese Journal of Immunology
2014;(6):821-824,830
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions and clinical significances of SMO , STAT3 and MMP-9 in triple negative breast cancer ( TNBC) .Methods:The expressions of SMO , STAT3 and MMP-9 were immunohistochemically detected in 33 cases of TNBC, 30 cases of mammary hyperplasia and 18 cases of normal breast tissue , and the relationships among SMO , STAT3 and MMP-9 and clinicopathological parameters and prognosis of TNBC patients were analyzed .Results:In TNBC and mammary hyperplasia tissue , the positive expression rates of SMO were 90.9%and 60.0%,the positive expression rates of STAT3 were 96.9% and 73.3%, the positive expression rates of MMP-9 were 90.9% and 36.7%, respectively, however, expressions of them were completely absent in normal breast tissue .The significant correlations were observed between expressions of SMO , STAT3 and MMP-9 in TNBC, mammary hyperplasia and normal breast tissue (P<0.05).The expression of SMO and STAT3 was correlated with superior histologic grade and tumor stage .The expression of MMP-9 was correlated with metastasis of lymph node .The positive correlation was manifested between SMO and STAT3(r=0.361,P<0.05),between SMO and MMP-9 (r=0.633,P<0.01),between MMP-9 and STAT3 (r=0.803,P<0.01) in TNBC.The survival time of TNBC patients was correlated with SMO expression and pTNM (P<0.05).Conclusion:SMO, STAT3 and MMP-9 may play important roles in development of TNBC and may be an important therapeutic target in TNBC .
