Association study of Uygur esophageal squamous cell carcinoma in Hp infected patients with cancer cell proliferation and invasion

VernacularTitle:探讨维族食管鳞癌病人Hp感染与癌细胞增殖及侵袭的关联研究
Author: Chengyu JIN ; Rui GUO ; Jinshan MA ; Erlan NU ; Xianfeng LI
Publication Type:Journal Article
Keywords: Hp; Ki67; MMP-2; Esophageal-carcinoma
From: Chinese Journal of Immunology 2014;(6):825-827,830
CountryChina
Language:Chinese
Abstract: Objective:To investigate the relationship between helicobacter pylori ( Hp) infection and proliferation as well as invasion of Uygur esophagus squamous cell carcinoma.Methods: Immunohistochemistry were used to detect Hp , Ki67 and MMP2 protein in 164 cases of Xinjiang Uygur esophageal squamous cell carcinoma tissue specimens.Results: The positive rates of Hp,Ki67 and MMP2 were 81.7%(134/164),67.1%(110/54) and 86.6%(142/164) respectively in 164 cases of esophageal squamous cell carcinoma.The expression of Ki67 in the Hp positive group of patients with esophageal squamous cell carcinoma were significantly higher than that in the Hp negative group and had positive correlation between them (rs=0.340,P<0.01),the expression of MMP2 in the Hp positive group were significantly higher than that in the Hp negative group and had positive correlation between them ( rs=0.739,P<0.01).Conclusion:The relationship between Xinjiang Uygur esophageal squamous cell carcinoma patients with Hp infection and cancer cell malignant degree of proliferation and invasion is close.