A 13-week subchronic toxicity test of Danhong injection in Beagle dogs
10.3969/j.issn.1671.7856.2014.006.006
- VernacularTitle:丹红注射液对 Beagle 犬的13周亚慢性毒性试验
- Author:
Fuyan CHI
;
Xuedong DAI
;
Yukui MA
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
Danhong injection;
Beagle dog;
Subchronic toxicity
- From:
Chinese Journal of Comparative Medicine
2014;(6):27-29,34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the subchronic toxicity of a Chinese medicine Danhong injection in dogs . Methods Twenty-four healthy Beagle dogs (body weigh 7-9 kg, male:female=1:1) were used in this study.The test dogs were administered with Danhong injection by intravenous injection once every day for consecutive 6 days/week for thirteen weeks.The Danhong injection was used in 3 doses:494,247,and 124 mg· kg-1, repectively.The control dogs received normal saline injection in the same volume .The body weight, blood biochemistry, hematology, viscera relative weight and histopathology were determined for the overall toxicity assessment .Results The dogs administered with 494 g· kg-1 Danhong injection showed significantly reduced body weight gain , abnormal increase of urea nitrogen ( BUN ) , creatinine (CR) levels, and histopathological changes in the liver .Conclusions Danhong injection (494mg· kg-1 ) administered Intravenously has obvious toxicity on the liver and kidney function .
