Effects of p38 MAPK in inflammation reaction of severe acute pancreatitis
- VernacularTitle:p38 MAPK在重症胰腺炎炎症反应中的作用研究
- Author:
Haifeng GUO
;
Huayang LI
;
Tieling LI
- Publication Type:Journal Article
- Keywords:
p38 MAPK;
severe acute pancreatitis;
inflammation reaction
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):19-20,23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of p38 MAPK gene and p38 MAPK protein,and explore the effect of p38 MAPK in inflammation reaction of severe acute pancreatitis.Methods 48 cases with severe acute pancreatitis were chosen as research group,and another 48 healthy cases as control group.The expression of p38 MAPK gene were investigated by RT-PCR,and the expression of p38 MAPK and P-p38 MAPK protein were investigated by western blot. Results The expression of p38 MAPK mRNA,p38 MAPK protein and P-p38 MAPK protein in research group were higher than that in control group,the differences were all statistically significant(P<0.05 ).Conclusion The expression of p38 MAPK gene and p38 MAPK protein were significantly increased in patients with severe acute pancreatitis,which showed that p38 MAPK played an important role in inflammation reaction.
