Regulation of paclitaxel on vascular endothelial related factors of serum and tissues in patients with uterine cancer
- VernacularTitle:紫杉醇对子宫癌患者血清及组织中血管内皮相关因子的调节作用
- Author:
Yan JIN
;
Xia LI
- Publication Type:Journal Article
- Keywords:
paclitaxel;
uterine cancer;
IL-8;
TNF;
TSGF
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):91-92,97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the regulatory effect of paclitaxel injection on vascular endothelial related factors in serum of uterine cancer patients.Methods 30 cases of uterine cancer patients treated with paclitaxel (observation group)and 30 cases of uterine cancer patients treated with surgery (control group)were selected.Chemiluminescence immunoassay (CLIA)was used to detect expressions of serum tumor necrosis factor(TNF), Interleukin-8(IL-8)and tumor specific growth factor (TSGF).Results Before treatment,there was no significant difference between the serum TNF, IL-8 and TSGF in observation group and control group(P<0.05).At 3 months after treatment,the serum TNF,IL-8 and TSGFwere significantly lower than before treatment ,which was statistically significant(P<0.05).Conclusion Paclitaxel can decrease serum TNF,IL-8 and TSGF in patients with uterine cancer,which provides a new theoretical basis for its anticancer effects.
