Comparison of the curative effect of three therapeutic regimens on H22 hepatoma-bearing mice
10.3969/j.issn.1005-4847.2014.03.014
- VernacularTitle:不同治疗方案对 H22肝癌荷瘤小鼠的疗效比较
- Author:
Yuanyuan ZHANG
;
Zhaoqin FANG
;
Yanming WANG
- Publication Type:Journal Article
- Keywords:
Hepatocarcinoma;
Mouse;
Therapeutic regimens;
Curative effect
- From:
Acta Laboratorium Animalis Scientia Sinica
2014;(3):67-71,77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effect of three treatment regimens on H 22 tumor-bearing mice. Methods H22 tumor-bearing mice were treated by local injection of compound chemotherapeutic agents (5-FU, mitomy-cin and cisplatin ) , oral administration of sorafeni , or the both combined , respectively .Standardized and quantitative syn-drome differentiation methods were used to assess the syndromes and tumor-inhibition rate in the mice .Results All these three therapeutic regimens were effective in suppressing the tumor growth in mice .Among them, the combined therapeutic regimen of local injection of compound chemotherapeutic drugs plus oral administration of sorafeni was the best .Conclu-sion The effect of sorafenib combined with local injection of compound chemotherapeutic agents is better than the other two regimens used separately .
