Combined detection of serum CEA,CA199 and CA724 in the diagnosis of gastric cancer
10.3969/j.issn.1673-4130.2014.12.010
- VernacularTitle:3项肿瘤特异性抗原联合检测对胃癌的诊断价值
- Author:
Fangqin LI
;
Xiao HAN
- Publication Type:Journal Article
- Keywords:
gastric cancer;
carcinoembryonic antigen;
CA724;
CA199
- From:
International Journal of Laboratory Medicine
2014;(12):1545-1546,1549
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of combined detection of serum carcinoembryonic antigen (CEA),car-bohydrate antigen 199 (CA199)and carbohydrate antigen 724 (CA724)for the diagnosis of gastric cancer.Methods Plasma levels of CEA,CA199 and CA724 were detected by using electrochemiluminescence in 95 patients with gastric cancer,63 patients with be-nign gastric diseases and 101 healthy subjects.Results Levels and positive rates of CEA,CA199 and CA724 in gastric cancer group were significantly higher than healthy control group (P<0.05).Levels and positive rates of CEA and CA724 in gastric cancer group were significantly higher than benign gastric diseases group (P<0.05).There was no statistically significant difference of level and positive rate of CA199 between gastric cancer group and benign gastric diseases group(P>0.05).The sensitivity of com-bined detection was obviously higher than any single detection or combined detection of two indexesConclusion Combined detection of the three tumor markers could improve the diagnostic sensitivity and coincidence rate,which have practical diagnostic value for gastric cancer.
