Normal-appearing white matter in children with developmental delay:a diffusion tensor imaging study
10.3969/j.issn.1002-1671.2014.06.024
- VernacularTitle:MRI 表现正常的脑发育迟缓儿童的脑白质 DTI 研究
- Author:
Li HE
;
Qingyun REN
;
Zhai LIU
;
Licun LEI
;
Yaqiang DU
- Publication Type:Journal Article
- Keywords:
developmental delay;
white matter;
diffusion tensor imaging;
fractional anisotropy value
- From:
Journal of Practical Radiology
2014;(6):987-990,1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of white matter microstructure by using DTI in children with developmental delay (DD)with normal routine MRI results.Methods We performed routine MRI and DTI in 23 children with DD and 23 age-matched normal children,FA values of five deep white matters (limb of internal capsule,anterior limb,genu and knee of corpus callosum and optic radiation)and four shallow white matters (frontal lobe,temporal lobe,occipital cortex,centrum ovale)were measured.FA values of the white matter for two groups were assessed by paired t tests for each region of interest.Results FA values on the deep white matter for DD,and on the deep white matter and the shallow white matter for normal development group increased with age significantly (P <0.05).FA values on the shallow white matter for DD were lower than that for normal development group,which had no significant correlation with age (P >0.05).The FA values on the shallow white matter and deep white matter (corpus callo-sum knee,optic radiation)for children with DD were lower than that for the control group (P <0.05),and the FA values of the limb of deep white matter (genu of corpus callosum,internal capsule and anterior limb)were no difference with the contorl group (P >0.05).Conclusion DTI may detect the changes of white matter microstructure in children with developmental delay,and provides an objective basis for quantitative diagnosis.
