Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells.
- Author:
Sung Lyea PARK
1
;
Bo Kyung LEE
;
Young Ae KIM
;
Byung Ho LEE
;
Yi Sook JUNG
Author Information
1. Department of Pathophysiology, College of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea. yisjung@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Urotensin II;
Urotensin II receptor antagonist;
Adhesion molecules;
Cytokines;
Tissue factor;
Endothelial cells
- MeSH:
Cytokines;
Endothelial Cells*;
Human Umbilical Vein Endothelial Cells;
Humans*;
Inflammation;
Interleukin-6;
Monocytes;
Thromboplastin;
Vascular Cell Adhesion Molecule-1
- From:Biomolecules & Therapeutics
2013;21(4):277-283
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, we investigated the effects of a selective urotensin II (UII) receptor antagonist, SB-657510, on the inflammatory response induced by UII in human umbilical vein endothelial cells (EA.hy926) and human monocytes (U937). UII induced inflammatory activation of endothelial cells through expression of proinflammatory cytokines (IL-1beta and IL-6), adhesion molecules (VCAM-1), and tissue factor (TF), which facilitates the adhesion of monocytes to EA.hy926 cells. Treatment with SB-657510 significantly inhibited UII-induced expression of IL-1beta, IL-6, and VCAM-1 in EA.hy926 cells. Further, SB-657510 dramatically blocked the UII-induced increase in adhesion between U937 and EA.hy926 cells. In addition, SB-657510 remarkably reduced UII-induced expression of TF in EA.hy926 cells. Taken together, our results demonstrate that the UII antagonist SB-657510 decreases the progression of inflammation induced by UII in endothelial cells.
