Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins.
- Author:
Su Hee HONG
1
;
Jee In HEO
;
Jeong Hyeon KIM
;
Sang Oh KWON
;
Kyung Mok YEO
;
Anna M BAKOWSKA-BARCZAK
;
Paul KOLODZIEJCZYK
;
Ok Hyun RYU
;
Moon Ki CHOI
;
Young Hee KANG
;
Soon Sung LIM
;
Hong Won SUH
;
Sung Oh HUH
;
Jae Yong LEE
Author Information
1. Department of Biochemistry, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea. jyolee@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Antidiabetes;
Purple corn anthocyanins;
Beta cell-protection;
Antihyperglycemic activity;
Pancreatic beta cell;
db/db Mice
- MeSH:
Animals;
Anthocyanins*;
Blood Glucose;
Cell Culture Techniques;
Cell Death;
Insulin;
Insulin-Secreting Cells;
Mice;
Passive Cutaneous Anaphylaxis;
Plants;
Polyphenols;
Zea mays*
- From:Biomolecules & Therapeutics
2013;21(4):284-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
