Clinical significance of changes of platelet parameters and aggregation rate in patients with acute cerebral infarction
10.3969/j.issn.1673-4130.2014.13.012
- VernacularTitle:急性脑梗死患者血小板参数及聚集率变化的临床意义
- Author:
Hongmei LIANG
;
Hua HUANG
;
Baojia DENG
;
Zhengwan GUO
;
Wanbing TANG
;
Zhibiao GAN
- Publication Type:Journal Article
- Keywords:
brain infarction;
platelet count;
platelet aggregation
- From:
International Journal of Laboratory Medicine
2014;(13):1694-1695,1698
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between platelet maximum aggregation rate(MAR),platelet thrombocyt-ocrit(PCT),platelet count(PLT),platelet distribution width(PDW)and mean platelet volume(MPV)with the course of acute cere-bral infarction(ACI)to provide the basis for its clinical early diagnosis and treatment.Methods 107 patients with ACI in our hospi-tal were selected and divided into the great infarction group(infarction size >10 cm3 ),middle infarction group(infarction size 4-10 cm3 )and small infarction group(infarction size<4 cm3 )according to the infarction lesion size by head CT or MRI and the infarction volume calculated by the Pullicino formula(length×width×layer number/2),40 healthy individuals were selected as the healthy control group.MAR,PLT,PDW,MPV and PCT were detected before and after the induction by PLR-06.Results (1 )Compared with the control group,PLT,PCT,PDW and MPV before the induction by PLR-06 in the great infarction group were obviously in-creased(P <0.01);PLT,PCT,PDW and MPV in the middle and small infarction groups were increased(P <0.05).(2)Compared with the control group,MAR after the induction by PLR-06 in each infarction group was increased(P <0.05);PLT had no statisti-cal difference among the groups(P >0.05 );PCT,PDW and MPV in the great and middle infarction groups were increased(P <0.05);PCT,PDW and MPV in the small infarction group had no statistical differences(P >0.05).Conclusion The change of the platelet aggregation rate,number and volume is closely related with the occurrence and development of ACI,monitoring their change has important clinical significance to prevention and treat ACI.
