Research progress on pharmacogenomics of antiretroviral drugs
10.3969/j.issn.1001-1978.2014.07.001
- VernacularTitle:抗逆转录病毒药物的基因组学研究进展
- Author:
Huan REN
;
Juan PENG
;
Zhi LI
- Publication Type:Journal Article
- Keywords:
AIDS;
antiretroviral therapy;
pharmacogenomics;
gene polymorphism;
pharmacogenetics;
individualized medica-tion
- From:
Chinese Pharmacological Bulletin
2014;(7):889-892,893
- CountryChina
- Language:Chinese
-
Abstract:
AIDS has become a global disease,and a variety of drugs are used in the treatment of AIDS ,but the interindividual variabilities in efficacy and toxicity remain important limitations for the use of these drugs.Studies have shown genetic polymor-phism is the main reason for interindividual variabilities of drug reaction.In recent years,scholars focused on the pharmacog-enomics of anti-AIDS drugs and found that genetic polymor-phisms,in large part,determine the interindividual variabilities of the responese of these drugs.This paper reviews the research progress on pharmacogenomics of the four types of anti-AIDS drugs commonly used in China,including nucleoside reverse transcriptase inhibitors (NRTIs),non-nucleoside reverse tran-scriptase inhibitors (NNRTIs),protease inhibitors (PIs)and integrase inhibitors (raltegravir).
