The effect of Dioscorea opposita polysaccharide in the treatment of rats with gastric ulcer and its influence on the level of EGF in gastric ulcer tissues

VernacularTitle:怀山药多糖对大鼠胃溃疡的疗效及胃组织表皮生长因子水平的影响
Author: Dingtian LUO ; Qiming LU ; Zhihong YANG ; Haiyan SHEN
Publication Type:Journal Article
Keywords: Ipomoea batatas; Polysaccharides; Stomach ulcer; Epidermal growth factor; Rats
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(15):2241-2242,2243
CountryChina
Language:Chinese
Abstract: Objective To observe the therapeutic effect of Dioscorea opposita polysaccharide on gastric ulcer in rats,and to investigate the effects of Dioscorea opposita polysaccharide on level of epidermal growth factor ( EGF) in stomach tissues .Methods 50 rats were randomly divided into five groups [ A group ( normal control group ) , B group(model group),C group(Dioscorea opposita polysaccharide group ),D group(teprenone group)].The healing condition of gastric ulcer and EGF level were observed and compared .Results (1)The ulcer index of C group was obviously reduced compared with B group (P<0.01).(2)Between C group and A group,the significant difference existed in the level of EGF(P<0.05),while the difference was not statistically significant between C group and D group(P>0.05).Conclusion Dioscorea opposita polysaccharide has protective effects for gastric mucosa .The mechanism of protection may be related to promote synthesis of EGF .