Study on the application effect of weekly dose of docetaxel combined with cisplatin and concurrent radiother-apy in the downstaging treatment of patients with esophageal carcinoma at at stage of ⅢA and ⅢB
10.3760/cma.j.issn.1008-6706.2014.16.025
- VernacularTitle:多西他赛联合顺铂同步放疗在ⅢA、ⅢB 期食管癌降期治疗中的应用
- Author:
Tingrong ZHANG
;
Yao ZHANG
;
Tao ZHAO
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Docetaxel;
Cisplatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(16):2454-2455,2456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the application effect of weekly dose of docetaxel combined with cisplatin and concurrent radiotherapy in the downstaging treatment of patients with esophageal carcinoma at at stage of ⅢA andⅢB.Methods 90 patients with locally advanced esophageal squamous cell carcinoma were the research object ,and they were divided into control group (PF group)45 cases and observation group (DP group)45 cases by using random number table method , then the clinical effect , adverse reaction rates and serum tumor markers before and after the treatment of two groups were analyzed ,and the analysis results were compared .Results The clinical effect of obser-vation group(64.44%)was better than those of control group (46.67%)(χ2 =3.97,P<0.05),and the serum tumor markers were lower than those of control group (t=4.11,3.84,3.29,all P<0.05),there were all significant differ-ences,while the various adverse reaction rates of two groups had no significant differences (all P>0.05).Conclusion The application effect of weekly dose of docetaxel combined with cisplatin and concurrent radiotherapy in the down -staging treatment of patients with esophageal carcinoma at at stage of ⅢA andⅢB is better ,and the safety is worth af-firmation.
