The effect of butylphthalide combined with edaravone in the treatment of progressive cerebral infarction and its impact on neurological deficits and hemorheology
10.3760/cma.j.issn.1008-6706.2014.15.040
- VernacularTitle:丁苯酞联合依达拉奉治疗进展性脑梗死的疗效及对神经功能缺损和血液流变学的影响
- Author:
Hui YANG
;
Deku MA
;
Fenghui CHEN
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Butylphenol;
Edaravone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(15):2327-2328,2329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of butylphthalide combined with edaravone in the treatment of progressive cerebral infarction and its impact on neurological deficits and hemorheology .Methods 78 patients with progressive cerebral infarction were divided into the control group and observation group according to the random number table ,39 cases in each group .The two groups were given conventional treatment ,the control group was given edaravone on the basis of the conventional treatment ,while the observation group was given butylphthalide soft capsules and edaravone .All of the patients were given continuous medication for 12d.The degree of neurological deficit score,clinical assessment efficacy and adverse reactions were compared between the two groups .Results The total effective rate of the observation group was 89.74%,which was significantly higher than 66.67% of the control group(χ2 =11.672,P<0.05).After treatment,the NIHSS scores were decreased significantly (t=11.04,12.88,all P<0.05),that in the observation group was declined more significantly ,compared with the control group ,the differ-ence was statistically significant (t=10.93,P<0.05).After treatment,the fibrin level,blood viscosity and platelet aggregation of the observation group were significantly lower than those of the control group ( t=6.69,6.22,7.30,all P<0.05).Conclusion Butylphthalide combined with edaravone in the treatment of progressive cerebral infarction can significantly improve the patients'neurological symptoms ,reduce fibrin level ,blood viscosity and platelet aggrega-tion,and its security is good ,which is worth to be applied in clinical .
