Correlation analysis of lower respiratory tract bacterial colonization and airway inflammation in stable COPD patients

Huilun LU; Haichun HE; Libo LI

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Correlation analysis of lower respiratory tract bacterial colonization and airway inflammation in stable COPD patients

VernacularTitle:稳定期慢性阻塞性肺疾病患者下呼吸道细菌定植与气道炎症相关性分析
Author: Huilun LU ; Haichun HE ; Libo LI
Publication Type:Journal Article
Keywords: Pulmonary disease,chronic obstructive; Colonization; Sputum culture
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(14):2128-2129,2130
CountryChina
Language:Chinese
Abstract: Objective To detect sputum quantitative bacterial culture and sputum cell counts in stable chro -nic obstructive pulmonary disease (SCOPD) patients, and explore the correlation between lower airway bacterial colo-nization(LABC) and airway inflammation.Methods 47 patients with SCOPD were chosen ,all patients induced spu-tum specimens to sputum quantitative bacterial culture and sputum cell counts ,sputum and serum IL-8 levels were al-so detected.Results There were 13 patients whose bacterial colonization of the lower respiratory tract in patients was higher than 107CFU/mL.Serum IL-8 levels of 13 patients was ( 70.65 ±19.89 ) pg/mL, sputum IL-8 levels was (364.65 ±74.19)pg/mL,all significantly higher than those whose bacterial colonization of the lower respiratory tract lower than 107CFU/mL,(15.87 ±3.01)pg/mL and (146.65 ±28.11)pg/mL,there were statistically significant difference(t=13.43,9.76,all P<0.05).After 1-year follow-up,FEV1 decline(0.071 ±0.016)L in patients whose bacterial colonization of the lower respiratory tract≥107CFU/mL,it was significantly higher than those whose bacterial colonization of the lower respiratory tract <107CFU/mL;the frequency of acute exacerbation was (2.93 ±1.07) times,significantly more than those whose bacterial colonization of the lower respiratory tract <107CFU/mL,the differ-ences were statistically significant (t=5.43,6.54,all P<0.05).Conclusion Lower respiratory tract bacterial colo-nization in patients with SCOPD can aggravate the inflammatory response and increase degree of airflow limitation .