The influence of CYP4F2(rs2108622)gene polymorphism on the warfarin dose in old patients
10.3969/j.issn.1673-4130.2014.11.010
- VernacularTitle:老年患者CYP4F2（rs2108622）基因多态性对华法林剂量的影响
- Author:
Mingjuan TAN
;
Weiwei CUI
;
Feng CHEN
;
Yanping MEI
;
Yingdong GAO
- Publication Type:Journal Article
- Keywords:
warfarin;
CYP4F2;
gene polymorphism
- From:
International Journal of Laboratory Medicine
2014;(11):1400-1401,1404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of CYP4F2(rs2108622)polymorphism on the dose of warfarin in old patients(65 to 75 years old)who were treated with atrial fibrillation.Methods Sixty cases of old patients with atrial fibrillation were enrolled in the study.All the subjects had taken warfarin for 3 months,and the international normalized ratio(INR)maintained between 1.6 and 2.5.And the CYP4F2(rs2108622)variant were detected by PCR.Results The patients with CYP4F2(rs2108622)allele C/C scored significantly lower warfarin dose than patients with variant allele C/T and T/T (P < 0.05 ).Conclusion CYP4F2 (rs2108622)gene polymorphism have been related with warfarin dose in old patients.
