Analysis of CYP2C19 metabolism phenotypes distribution of 76 patients with clopidogrel treatment in Huangshi
10.3969/j.issn.1673-4130.2014.11.014
- VernacularTitle:黄石地区76例氯吡格雷治疗患者 CYP 2C19不同代谢表型的分布
- Author:
Zhongliang ZHU
;
Congrong LI
;
Hongliang WANG
;
Zhenlong LI
- Publication Type:Journal Article
- Keywords:
clopidogrel;
CYP2C19;
metabolism phenotype;
gene chip
- From:
International Journal of Laboratory Medicine
2014;(11):1410-1411,1414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of CYP2C19 metabolism phenotype in patients with clopidogrel treatment in Huangshi.Methods The peripheral blood samples were obtained from 76 patients with clopidogrel treatment in Cardiovascular Department.CYP2C19 genotypes were determined by the gene chip,CYP2C19 metabolism phenotype were investigated and com-pared with the data of healthy Han Chinese from the published papers.Results There were three kinds of metabolizers about the metabolism phenotypes of CYP2C19,which were extensive metabolizers,intermediate metabolizers and poor metabolizers.In the 76 patients,the ratios of these metabolism phenotypes were 39.47%,44.74% and 15.79%,respectively.The result coincided with the healthy Han Chinese.Conclusion The clinical individualized medication of healthy Han Chinese could be refered to the clinical indi-vidualized medication of patients with clopidogrel treatment in Huangshi.
