Role of mitochondrial calpains in apoptosis
10.3969/j.issn.1001-1978.2014.06.005
- VernacularTitle:线粒体calpains与细胞凋亡关系的研究进展
- Author:
Biwei SONG
;
Qiaomei FAN
;
Zhiyu HE
- Publication Type:Journal Article
- Keywords:
mitochondria;
Ca2+;
μ-calpain;
m-calpain;
cal-pain10;
apoptosis
- From:
Chinese Pharmacological Bulletin
2014;(6):757-759,760
- CountryChina
- Language:Chinese
-
Abstract:
Calpains are the family of Ca2+-activated cysteine pro-teases. Although calpains are considered to be cytoplasmic en-zymes, recent research has demonstrated that μ-calpain, m-cal-pain, calpain 10 and their endogenous inhibitor calpastatin are present in the mitochondria and play important roles both in caspase -dependent and-independent pathways in cell death phe-nomena. Calpains exert direct and indirect effects on the caspases
and regulators of apoptosis pathway such as Bcl-2, Bax, Bid, promoting the release of Cyt-C, AIF, then result in cellular ap-optosis. To allow pharmacological targeting of these enzymes, thorough knowledge of their patterns of activation and further in-teractions with already known apoptotic pathways is necessary.
