Prognostic value of lymph node status evaluated by computed tomography for patients with cervical cancer treated with radical chemoradiation therapy
10.3760/cma.j.issn.1006-9801.2014.05.005
- VernacularTitle:盆腔淋巴结CT检测对根治性放化疗子宫颈癌患者生存的预测价值
- Author:
Wenjia XIE
;
Liya ZHOU
;
Yanfeng GAO
;
Tiantian ZHAI
;
Lili WU
;
Liangxi XIE
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Radical chemoradiation therapy;
Lymph node metastasis;
Computed tomography;
Prognostic factor
- From:
Cancer Research and Clinic
2014;26(5):306-309,314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of lymph node status evaluated by computed tomography (CT) in cervical carcinoma treated with radical chemoradiation therapy.Methods 209 patients with FIGO stage Ⅰ B-ⅣA uterine cervical carcinoma treated with radical chemo radiation therapy were enrolled.Lymph node status was evaluated based on site,number and size respectively by CT.Kaplan-Meier method was used to analyze the impact of lymph node status as well as other pathoclinical factors on overall survival (OS).Cox regression model was used to explore the relationship between independent prognostic factors and OS.Results Lymph node metastasis rates for stage Ⅰ B,Ⅱ,Ⅲ and ⅣA patients were 16.7 ％ (1/6),48.2 ％ (68/141),57.4 ％ (31/54) and 87.5 ％ (7/8),respectively.Variate analysis showed that FIGO stage,anemia before treatment,para-aortic lymph node metastasis,and the number (≥3) and size (maximum diameter ≥ 2.0 cm) of CT positive lymph node were significant unfavorable prognostic factors for OS (P ＜ 0.05).FIGO stage,the number of lymph nodes metastasis,pathologic diagnosis and treatment regimen were identified to be independent prognostic factors in multivariate analysis.Conclusion Under current therapeutic strategy of concomitant chemoradiotherapy,lymph node metastatic status evaluated by pretreatment CT is still a significant and independent prognostic factor for cervical cancer.
