The expression level of serum IL-7 and its influence on prognosis in patients with acute coronary syndrome
10.3969/j.issn.1008-0074.2014.06
- VernacularTitle:急性冠脉综合征患者血清IL-7的表达水平及其对预后的影响
- Author:
Daixing ZHOU
;
Dingmiao WANG
;
Chengye ZHAN
;
Li YAN
;
Qiang ZHONG
;
Shusheng LI
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Interleukin-7;
Prognosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(6):597-601
- CountryChina
- Language:English
-
Abstract:
Objective: To explore the expression level of serum interleukin (IL)-7 in patients with acute coronary syndrome (ACS) and analyze the relationship between IL-7 level and prognosis. Methods: A total of 130 ACS patients [ACS group, including 70 cases with acute myocardial infarction (AMI) and 60 cases with unstable angina pectoris (UAP)], 33 cases with stable angina pectoris (SAP，SAP group) and 89 healthy subjects (healthy control group) were selected. IL-7 level was measured using enzyme linked immunosorbent assay (ELISA) and compared among all groups. The 130 ACS patients were followed up, and Logistic regression analysis was used to analyze the relationship between IL-7 level and prognosis. Results: Compared with healthy control group and SAP group, there was significant rise in IL-7 level in UAP group and AMI group [(1.84±0.47) pg/ml, (2.11±0.63) pg/ml vs. (4.87±0.52) pg/ml, (5.15±0.71) pg/ml, P<0.05 or P<0.01]. There were no significant difference in IL-7 level between healthy control group and SAP group, UAP group and AMI group (P>0.05 both); Logistic regression analysis indicated that expression level of serum IL-7 was an independent risk factor for adverse cardiovascular events in ACS patients (OR=1.212, 95%CI:1.061-1.418). Conclusion: Interleukin-7, as an important inflammatory cytokines, its serum level abnormally elevated in patients with acute coronary syndrome, it may have important prognostic value.
- Full text:P020150213534983699030.doc
