Correlation between serum high molecular weight adiponectin level and arteriosclerosis
10.3969/j.issn.1008-0074.2014.05.01
- VernacularTitle:血清高分子量脂联素水平与动脉硬化的相关性
- Author:
Chao LIU
;
Taolin ZHENG
;
Wanhong DU
;
Youshuo LIU
;
Zhaofeng LONG
;
Yanjiao WANG
;
Ying TIAN
;
Junkun ZHAN
- Publication Type:Journal Article
- Keywords:
Arteriosclerosis;
Hyperlipidemia;
Adiponectin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(5):475-479
- CountryChina
- Language:English
-
Abstract:
Objective: To explore the correlation between serum level of high molecular weight adiponectin (HMW-ADPN) and arteriosclerosis. Methods: Clinical data of 87 middle-aged and aged people living in home, who underwent health examinations in Xiangya second hospital from Jan 2011 to Dec 2011, were collected. According to carotid-femoral pulse wave velocity (cf-PWV) = 9 m/s, they were divided into group A (cf-PWV<9 m/s, n=21) and group B (cf-PWV≥9 m/s, n=66). Blood pressure, blood lipid, blood glucose etc. were measured and compared between two groups. Results: Compared with group A, there were significant rise in blood pressure, levels of low density lipoprotein cholesterol, triglyceride and total cholesterol, and significant reduction in levels of high density lipoprotein cholesterol (HDL-C), serum total ADPN and HMW-ADPN in group B, P<0.05 or <0.01. Multiple regression analysis indicated that serum HMW-ADPN (B= - 4.469，P=0.011), total ADPN ((B= - 3.965，P=0.012), HDL-C（B= - 2.077，P=0.015) and systolic blood pressure levels (B= 0.045，P=0.045) were independent predictors of cf-PWV. Conclusion: Serum high molecular weight adiponectin and total adiponectin levels may be protective factors against arteriosclerosis. Its role in predicting occurrence and development of arteriosclerosis is worthy of further study.
- Full text:P020150213525056828609.doc
