A clinical study of serum lipid metabolism and immunoregulation of patients with primary nephritic syndrome
10.3969/j.issn.1673-4130.2014.09.015
- VernacularTitle:原发性肾病综合征患者血脂代谢及免疫调节的临床研究
- Author:
Xiaomeng CHEN
;
Jianrong SU
- Publication Type:Journal Article
- Keywords:
primary nephrotic syndrome;
serum lipid metabolism;
immunoregulation
- From:
International Journal of Laboratory Medicine
2014;(9):1124-1125,1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the serum lipid metabolism and immunoregulation of patients with primary nephritic syndrome (PNS) .Methods 50 PNS patients were served as the test group and 50 healthy people the control group .Automatic biochemical analyzer was utilized to detect their serum low density lipid-cholesterol (LDL-C ) ,high density lipid-cholesterol (HDL-C ) , triglyceride(TG) ,total cholesterol(TC) ,apolipoprotein(Apo)A1 ,ApoB ,and lipoprotein (a) .Immunization rate nephelometry was employed to measure their serum IgG ,IgA ,IgM ,complement C3 ,complement C4 ,CD3+ ,CD4+ ,CD8+ and CD4/CD8 .Results Compared with the control group ,serum levels of TC ,TG ,LDL-C ,ApoB ,ApoA1 ,IgM and CD4/CD8 of patients in the test group were significantly higher ,while those of HDL-C ,IgG ,complement C3 ,complement C4 ,CD3+ ,CD4+ ,CD8+ were obviously lower , with both statistically significant differences (P<0 .05) .However ,the differences of serum lipoprotein (a) and IgA between the two groups was not statistical significant(P>0 .05) .Conclusion Serum lipid level of PNS patients is higher than healthy people ,and considerable loss of Ig and complements and T cell subsets disproportion results in humoral and cellular immune dysfunction .
