A study on diagnostic value of serum human epididymis protein 4 detection for ovarian cancer
10.3969/j.issn.1673-4130.2014.09.017
- VernacularTitle:血清人附睾蛋白4检测对卵巢癌的诊断价值研究
- Author:
Zongbo CHEN
;
Zhanze CHEN
;
Guoxuan LI
;
Biyun ZHOU
;
Weiqi LIU
;
Ziping LI
- Publication Type:Journal Article
- Keywords:
ovarian neoplasms;
diagnosis;
human epididymis protein 4
- From:
International Journal of Laboratory Medicine
2014;(9):1129-1130,1133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of serum human epididymis protein 4 (HE4 ) for ovarian cancer . Methods Electrochemiluminescence immunoassay was employed to detect the serum HE 4 of 91 patients with ovarian cancer (ovari-an cancer group) ,69 patients with benign ovarian disease(benign group) and 60 healthy people(control group) .Area under the curve(AUC ) of receiver operator characteristic (ROC ) curve for HE4 was calculated .Results Serum HE4 level [(146 .81 ± 81 .29)pmol/L] of patients in ovarian cancer group was significantly higher than those in control group [(43 .16 ± 25 .64) pmol/L] and benign group[(59 .86 ± 39 .87) pmol/L](P<0 .01) .Set serum HE4≥140 pmol/L as positive cutoff value ,the diagnostic sensi-tivity of serum HE4 detection for ovarian cancer was 82 .4% (75/91) ,specificity 89 .9% (62/69) and diagnostic efficiency 85 .6% . Serum HE4 levels of patients with serous adenocarcinoma ,endometrial adenocarcinoma or other ovarian cancer were markedly high-er than that with mucinous adenocarcinoma (P<0 .01) .Serum HE4 levels of patients with stage Ⅲ ,Ⅳ ovarian cancer were obvious-ly higher than those with Ⅰ ,Ⅱ stage(P<0 .01) .Conclusion HE4 detection has clinical value for the auxiliary diagnosis of ovarian cancer .
