Preparation and Drug Release in vitro of Indometacin Enteric Dropping Pills
- VernacularTitle:吲哚美辛肠溶滴丸的研制及其体外释药研究
- Author:
Yongjun HU
- Publication Type:Journal Article
- Keywords:
Indometacin;
Enteric;
Dropping pills;
Drug release in vitro
- From:
China Pharmacist
2014;(5):713-715,716
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare indometacin ( IDM) enteric dropping pills and study the drug release in vitro. Methods:Using PEG6000 as the base, the optimal formula and preparation process of IDM dropping pills were screened by an orthogonal design. IDM dropping pills were coated by polyacrylic resin II as the enteric coating material. Compared with the marketed IDM enteric tablets, the drug release of IDM enteric dropping pills in vitro was studied using a suspended basket method. Results:The optimal preparation con-ditions of IDM dropping pills were as follows:the ratio of IDM and base was 1∶3, the dropping speed was 65 drops/min, the dropping temperature was 90℃ and the temperature of the cooling solvent was 5℃. IDM dropping pills and the marketed tablets were both with little drug release in acidic solvent. In pH 6. 8 phosphate buffer solution, IDM enteric dropping pills showed much quicker drug release than the marketed enteric tablets (P<0. 05). Conclusion:IDM enteric dropping pills exhibit enteric effect and quick drug release in vitro, which are valuable to be studied further.
