A Case of Primary Colon Amyloidosis Presenting as Hematochezia.
- Author:
Yong Hwan KWON
1
;
Ji Yeon KIM
;
Ji Hun KIM
;
Hyun Woo PARK
;
Hae Min YANG
;
Seong Woo JEON
;
Sung Kook KIM
Author Information
- Publication Type:Case Reports ; English Abstract
- Keywords: Amyloidosis; Gastrointestinal hemorrhage; Colon
- MeSH: 6-Mercaptopurine/analogs & derivatives/therapeutic use; Amyloidosis/*diagnosis/drug therapy/pathology; Antimetabolites/therapeutic use; Colon/pathology; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Steroids/therapeutic use; Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology 2012;59(1):44-47
- CountryRepublic of Korea
- Language:Korean
- Abstract: Amyloidosis is characterized by a deposition of insoluble fibrils in various organs and tissues. Amyloid deposition, in the gastrointestinal track, provokes a dysfunction of the organ, due to an accumulation of fibrils, and causes a variety of clinical symptoms and endoscopic findings. Primary amyloidosis in the gastrointestinal tract is rarely reported in Korea. We experienced a case of recurrent intestinal bleeding, in a 59-year-old female patient with primary amyloidosis. A colonoscopy revealed the presence of multiple large circular ulcers. In the entire colon, diffuse nodular lesions with edema and bleeding were found. A colonoscopic biopsy established the diagnosis of amyloidosis, to the exclusion of other disease components. We concluded that the patient had localized amyloidosis. Though a definitive therapeutic strategy has not been established for localized gastrointestinal amyloidosis, the patient has been successfully treated with a high-dose of steroids and azathioprine.
