Prediction of secondary structure and B-cell epitope of human IL-37
10.3969/j.issn.1000-484X.2014.05.017
- VernacularTitle:人白细胞介素37的二级结构及B细胞表位预测
- Author:
Qiaoyan GAO
;
Yan LI
;
Mi ZHOU
;
Xueming GAO
;
Xianli YUAN
;
Mingcai LI
- Publication Type:Journal Article
- Keywords:
IL-37;
B cell epitope;
Secondary structure
- From:
Chinese Journal of Immunology
2014;(5):648-650,653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To predict the secondary structure and B-cell epitope of human IL-37.Methods:Based on IL-37b ami-no acid sequence, the secondary structure was predicted by SOPMA; hydrophilicity, flexibility, accessibility index were predicted by software of ProScale, Bcepred, respectively.Combined the results according to these methods , the B cell epitopes of IL-37b were pre-dicted.Results: The second structure of IL-37b contained extended strand (31.65%), random coil (52.75%), alpha helix (8.26%), beta turn (7.34%) and the most possible epitopes of IL-37b were located in or adjacent to amino acid 21-27, 34-75, 175-192 , 213-215 .Conclusion:These results will be helpful for the estimate of the epitopes and provide a theory basis for developing mon -oclonal antibodies against human IL-37.
