Expression and significance of HIF-1α, HIF-2αand MT in human papillary thy-roid carcinoma
10.3969/j.issn.1000-484X.2014.05.020
- VernacularTitle:HIF-1α、HIF-2α和MT在人甲状腺乳头状癌中的表达及其意义
- Author:
Ni WANG
;
Chaoran DONG
;
Cui TANG
;
Lei YANG
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
HIF-1α;
HIF-2α;
MT
- From:
Chinese Journal of Immunology
2014;(5):662-665,676
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of HIF-1α, HIF-2αand MT in human papillary thyroid carcinoma ( PTC) and the association of their expression with clinicopathological indicators .Methods:Immunohistochemistry was used to analyze the ex-pression of HIF-1α, HIF-2αand MT in 70 PTC samples .The correlations of HIF-1α, HIF-2αand MT expression with one another , and with several clinicopathological indicators were statistically analyzed .Results:In 70 PTC samples, the positive expression rates of HIF-1α, HIF-2αand MT were 52.86%(37/70), 50.00%(35/70) and 44.29%(31/70), respectively.HIF-1α, HIF-2αand MT expression had significant correlations with cervical lymph node metastasis (P=0.034, P=0.022, and P=0.032, respectively). Meanwhile, HIF-1αexpression had a positive correlation with HIF-2α(rs =0.258, P=0.031) and MT (rs =0.266, P=0.026). HIF-2αand MT expression were positively correlated (rs=0.259, P=0.030).Concomitant expression of any two or all of the three molecules had stronger correlation with lymph node metastasis than did each alone ( P=0.004 for HIF-1α/HIF-2α, P=0.024 for HIF-1α/MT, P=0.029 for HIF-2α/MT, P=0.017 for HIF-1α/HIF-2α/MT).Conclusion:HIF-1α, HIF-2αand MT expression in PTC samples have a closely correlation , which are related to cervical lymph node metastasis .Therefore, the expression of HIF-1α, HIF-2αand MT might be used as biomarkers for cervical lymph node metastasis of PTC .
