The dysregulated expression of TNF-αfor spastic cerebral palsy
- VernacularTitle:TNF-α在痉挛型脑瘫中的异常表达
- Author:
Xueming LIN
;
Jianxian WU
- Publication Type:Journal Article
- Keywords:
cerebral palsy;
immune factor;
tumor necrosis factor-alpha
- From:
Acta Universitatis Medicinalis Anhui
2014;(5):692-693,697
- CountryChina
- Language:Chinese
-
Abstract:
82 spastic cerebral palsy and normal children were selected, including 27 younger and 27 older spastic cerebral palsy( observation group) ,and 14 younger and older normal children( control group) . The tumor necrosis factor α( TNF-α) levels were measured in the serum with ELISA. The TNF-α levels in the serum of the younger and older spastic CP groups were higher than those of the control groups ( P<0.01 ) . In observation groups, the TNF-α levels of younger spastic cerebral palsy were higher than those of the older (P<0.01). On the contrary, the normal children in the control group of different ages had no difference of TNF-α. TNF-αexpression was signifi-cantly higher in the serum of the spastic CP group than that in the control group ( P<0.01 ) . TNF-α expressed continuously in vivo of children with spastic cerebral palsy involve subsequent brain injury.
