Comparative Study of the Character of Release in vitro between New MU-AN Ophthalmic Gel and the Old
- VernacularTitle:新目安眼用凝胶剂与目安眼用凝胶剂体外释药特性比较研究
- Author:
Haiying XIAO
;
Chang GUO
;
Qun HE
;
Guangyu CHEN
;
Shi WANG
;
Biqing ZHAO
;
Lue HUANG
- Publication Type:Journal Article
- Keywords:
New MU-AN ophthalmic gel;
MU-AN ophthalmic gel;
Ganciclovir;
Acyclovir;
Drug release in vitro
- From:
China Pharmacist
2014;(4):574-577,578
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To search the release in vitro of new MU-AN ophthalmic gel consist of ganciclovir instead of aciclovir is whether better than the Old. Methods:Using the content of ganciclovir and acyclovir as the index, taking the second oar method ( in Ch. P 2010), drug release in vitro test was investigated. Results:The character of drug release of new MU-AN ophthalmic gel was e-qual to the old, the rate of drug release was similar, The amount of drug release was the same. Both drugs met the requirements of clin-ical medication. The character corneal permeability of new MU-AN ophthalmic gel was better than the old. Gel matrix had no influ-ences on drug release, drug would be bring treatment effect after the way that it was released quickly then was dissolved in tear. Con-clusion:The drug release characteristics consistent with ophthalmic preparation requirements. The character of drug release of new MU-AN ophthalmic gel consist of ganciclovir instead of aciclovir is equal to the old, the time administer drug and interval time is gener-ally scientific, reasonable and feasible, providing the basis for the pharmacodynamics , toxicology and clinical study in the next step.
