Study on the association of prehepatic fat thickness with insulin resistance in women with polycystic ovarian syndrome

VernacularTitle:多囊卵巢综合征患者肝前脂肪厚度与胰岛素抵抗的相关性研究
Author: Yanhong YANG ; Huijie YANG
Publication Type:Journal Article
Keywords: Polycystic ovary syndrome; Liver; Adipose tissue; Insulin resistance
From: Journal of Chinese Physician 2014;16(3):339-340,343
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of prehepatic fat thickness with insulin resistance in women with polycystic ovarian syndrome (PCOS).Methods Thirty-five PCOS patients and 39 controls were randomly enrolled in the study.Prehepatic fat thickness was detected by ultrasound,and fasting glucose (FBG),fasting insulin (FINS),and serum lipids were detected.The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance.Results Prehepatic fat thickness was significantly higher in PCOS patients than healthy controls,and prehepatic fat thickness were significantly correlated with HOMA-IR (P ＜ 0.05).The receiver operating characteristic (ROC) curve demonstrated that prehepatic fat thickness had higher sensitivity and specificity in diagnosing PCOS with insulin resistance.Conclusions This study demonstrates that prehepatic fat thickness significantly correlates with insulin resistance and can be used as the markers of insulin resistance in PCOS patients.