Expression and clinical significance of Id1 and relationship between Id1 and prognosis of patients with hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2014.04.009
- VernacularTitle:Id1在人肝癌组织中的表达意义及其与肝癌患者预后的关系研究
- Author:
Rui DING
;
Xiao LI
;
Ti ZHOU
;
Kefeng DOU
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Hepatitis B virus;
Inhibitor of differentiation protein
- From:
International Journal of Surgery
2014;41(4):239-243,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of Id1 and HBx in HBV-related hepatocellular carcinoma (HCC) tissue samples and analyzed the correlation between Id1 expression levels and clinicopathological features of patients.Methods Tumor tissue samples obtained from a total of 113 HCC patients.The expression of Id1 proteins of these samples were detected by immunohistochemical (IHC) staining and evaluated by two independent pathologists.The corrections between the clinical pathological parameters and the IHC scores for Id1and the prognostic significance were statistical analyzed by SPSS 19.0 software.Results Ninty-six of 113 patients is HBV-related HCC.Over-expression of Id1 were found positively correlated with the HBsAg ＞ 200 s/n,histological grade,portal vein invasion.Patients with Id1 overexpression had both shorter disease-free and overall survival times.Conclusions High expression of Id1 was correlated with serum HBsAg,histological grade,portal vein invasion and poor clinical outcomes in HBV-related HCC.
