A cross-sectional study on the association between platelet-activating factor acetylhydrolase gene polymor-phism and cerebral artery atherosclerotic stenosis
10.3936/j.issn.1002-0152.2014.03.003
- VernacularTitle:血小板活化因子乙酰水解酶基因多态性与脑动脉粥样硬化性狭窄的关联性研究
- Author:
Yumin CAO
;
Xiong ZHANG
;
Long LONG
;
Xin WAN
;
Shou WANG
;
Chenbo DAI
;
Guixian MA
;
Tengyun MA
;
Zhexian YANG
;
Yuhu ZHANG
;
Lijuan WANG
- Publication Type:Journal Article
- Keywords:
Platelet-activating factor acetylhydrolase;
Gene polymorphism;
Cerebral artery atherosclerosis ste-nosis;
Cerebral infarction;
Cerebral digital subtraction angiography
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(3):138-142,148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between platelet-activating factor acetylhydrolase gene Arg92His(4, 275; G→A), Ile198Thr(7, 593; T→C) and Val279Phe(9, 994; G→T) mutation and cerebral artery athero-sclerosis stenosis. Methods Six hundred forty-twopatients with cerebral infarction underwent cerebral digital subtrac-tion angiography (DSA).The patients were then divided into cerebral artery atherosclerosis stenosis (CAAS) group(n=477) and control group(n=81) accroding to the site and severity of their cerebral artery stenosis. Furthermore, the CAAS group were divided into intracranial artery stenosis(ICAS) subgroup(n=251), extracranial artery stenosis(ECAS) subgroup (n=115) and extracranial-intracerebral artery stenosis(ECAS) subgroup(n=111). The distributions of genotype and allele frequencies of Arg92His,Ile198Thr and Val279Phe mutation of platelet-activating factor acetylhydrolase gene were ex-amined and comparied in different groups. Results There were significant differences in the distributions of genotype and allele of Arg92His mutation between ICAS subgroup and control group(42.6% vs. 30.3%;23.3% vs. 16.4%, P <0.05). These associations were not detected in ECAS and IECAS subgroups. There was no significant association be-tween Ile198Thr and Val279Phe and stenosis at any site(P>0.05). The distributions of genotype and allele of Arg92His, Ile198Thr and Val279Phe mutation were no significantly difference between CAAS group and control group (P >0.05). Conclusions Arg92His mutation may be associated with intracranial artery atherosclerotic stenosis.
