Clinical Study on Compound Sophora Injection Combined with Java Brucea Fruit Oil Emulsion for Palliative Treatment of Advanced Malignant Tumors
10.3969/j.issn.1005-5304.2014.05.009
- VernacularTitle:复方苦参注射液联合鸦胆子油乳注射液姑息治疗晚期恶性肿瘤临床研究
- Author:
Xiue YANG
;
Yanmei REN
;
Wugang REN
;
Jinke YE
- Publication Type:Journal Article
- Keywords:
compound sophora injection;
Java brucea fruit oil emulsion injection;
advanced malignant tumor;
palliative treatment
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(5):28-30,33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the short-term clinical effect of compound sophora injection combined with Java brucea fruit oil emulsion injection for palliative treatment of advanced malignant tumors. Methods Totally 120 cases of advanced malignant tumor patients were randomly divided into treatment group and control group, each contains 60 cases. The control group was treated with Java brucea fruit oil emulsion, and the treatment group took compound sophora injection additionally by intravenous infusion one time daily. The cycle was 24 d. After 3 cycles, the curative effect, pain relief, improvement situation of quality of life and adverse reactions of the two groups were observed. Results Feasible curative effect evaluation of 112 patients showed:The disease control rate in the treatment group was 89.5% (51/57), and the control group was 74.5% (41/55). The total effective rate of cancer pain relief of the treatment group was 91.2%(52/57), and the control group was 70.9% (39/55). The improvement rate of life quality of the treatment group was 70.2% (40/57), and the control group was 49.1% (27/55). The differences between the two groups was significant (P<0.05). There was no difference in hematology toxicity, liver and kidney function, gastrointestinal adverse reactions and itchy skin incidence between the two groups (P>0.05). And the treatment group had a lower incidence of phlebitis than the control group (P<0.05). Conclusion Compound sophora injection combined with Java brucea fruit oil emulsion for palliative treatment can improve curative effect, significantly improve patients’ quality of life, it was a safe and effective way in treating advanced malignant tumors.
