Efficacy analysis of preoperative 3-dimensional conformal radiotherapy in 32 cases of large nephroblastoma
10.3760/cma.j.issn.1006-9801.2014.04.006
- VernacularTitle:巨大肾母细胞瘤32例术前三维适形放疗效果分析
- Author:
Yangjun YUE
;
Sha LI
;
Shihua WEI
;
Xianghui ZHU
;
Zhongze TIAN
;
Xiaohua CHEN
- Publication Type:Journal Article
- Keywords:
Nephroblastoma;
Radiotherapy;
Preoperative;
Prognosis
- From:
Cancer Research and Clinic
2014;26(4):235-237,240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effectiveness of the preoperative 3-dimensional conformal radiotherapy for large nephroblastoma up to 10 centimeters in diameter,and to investigate more effective preoperative therapies for intermediate and advanced nephroblastoma.Methods 32 cases of nephroblastoma were treated with preoperative radiotherapy with a dose fractionation as follows:150-200 cGy/fraction,5 fraction/week,the total dose of 1 000-2 000cGy,the mean dose of 1 600 cGy.During the radiotherapy,the B ultrasonic examination and CT were performed weekly to measure the variation of tumor volumes.The time of operation were determined based on the overall health status of patients,the shrinkage of tumor,and adhesions between tumor and adjacent vital organs.Radiontherapy was terminated one week before operation.4 patients who were found tumor adhered to normal tissues around kidney during operation were placed silver clip,and were given postoperative radiotherapy with additional dose of 1 000-2 000 cGy and the mean dose of 1 200 cGy.Results The median tumor reduction rate was 37 ％.The effective rate of preoperative radiotherapy was 100 ％.The complete resection rate was 87.5 ％.2-years tumor-free survival rates was 84.4 ％ and 5-years was 78.1％.There was no surgery-related death.Conclusion Preoperative 3-dimensional conformal radiotherapy reduces tumor volume,and raises resection and survival rate.
