Relationship of multi-slice spiral CT pulmonary perfusion imaging and the expression of VEGF and MVD in non-small cell lung cancer

VernacularTitle:多层螺旋CT肺癌灌注成像与VEGF表达和MVD的关系
Author: Tao FAN ; Qinfang HAN ; Donghua CAO ; Libo PAN ; Xuewu ZHAO ; Shusheng WANG ; Jun LI ; Yan ZHAO ; Shuang WEI
Publication Type:Journal Article
Keywords: perfusion imaging; microvascular density; vascular endothelial growth factor; non-small call lung carcinoma
From: Journal of Practical Radiology 2014;(4):617-619,678
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship of the expression of vascular endothelial growth factor (VEGF)and the mi-crovessel density (MVD)with multi-slice spiral CT perfusion imaging.Methods 80 patients with solitary pulmonary nodules under-went perfusion scan by 16-slice spiral CT.Among them,45 diagnosed as lung cancer by pathology were enrolled in the study.After surgery,the slice of the pecimen was selected similar to the corresponding slice of CT images,and the immunohistochemical staining was performed to determine the expression of VEGF and the MVD.Spearman correlation analysis was used to determine the rela-tionship of expression of VEGF and the MVD with CT perfusion parameters.Results There was more expression of VEGF and the MVD in NSCLC.There were positive correlations between VEGF,MVD and BF (both P<0.05).The peak enhancement image (PEI)and TTP have significant correlations with MVD (P<0.05).Conclusion Some parameters of lung CT perfusion imaging are correlated with MVD and VEGF.