Clinical studies of cerebrospinal lfuid replacement combined with Vancomycin and dexamethasone intrathecal injection on intracranial infection
- VernacularTitle:脑脊液置换联合万古霉素与地塞宋松鞘内注射对术后颅内感染的临床研究
- Author:
Zhifeng QU
;
Chunyan QU
;
Wenli CHEN
;
Zhiqiang WEN
;
Hui XIAO
- Publication Type:Journal Article
- Keywords:
cerebrospinal fluid replacement;
intrathecal injection;
intracranial infection;
biochemical markers
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(2):84-85,89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cerebrospinal lfuid replacement combined with vancomycin and dexamethasone intrathecal therapy on biochemical indicators of postoperative intracranial infection, in order to improve the clinical diagnosis and treatment. Methods 70 cases with intracranial infection collected in Third Hospital of Beijing Armed Police Corps from February 2010 to April 2013 were as subject, and randomly divided into two groups. Control group(n=35) were given cerebrospinal lfuid replacement and ceftriaxone intravenously, observation group(n=35) were given cerebrospinal lfuid replacement combined with vancomycin and dexamethasone intrathecal injection. The clinical effects and biochemical indicators were observed after treatment in two groups. Results In control group, the cure rate was 22.86%and total efifciency was 77.14%. In observation group, the cure rate was 37.14% and total efficiency was 91.43%. The differences between two groups were statistically significant (P<0.05). The differences of leukocytes, glucose, protein, intracranial pressure in two groups after treatment were also statistically signiifcant(P<0.05). Conclusion Cerebrospinal lfuid replacement combined with vancomycin and dexamethasone intrathecal injection therapy can increase intracranial infection.
