The risk factors analysis and control for intrahepatic cholestasis of pregnancy
10.3969/j.issn.1671-8348.2014.13.015
- VernacularTitle:妊娠期肝内胆汁淤积症的临床特点和发病危险因素分析
- Author:
Jianrong HUANG
- Publication Type:Journal Article
- Keywords:
cholestasis,intrabepatic;
pregnancy complications;
pregnancy outcome;
risk factors;
renal function;
drug control
- From:
Chongqing Medicine
2014;(13):1573-1575,1578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and risk factors for intrahepatic cholestasis of pregnancy(ICP), and put forward relevant control measures.Methods May 2009 to February 2013 in our hospital maternity clinic built card ICP 60 cases of pregnant women as the observation group,choosed the same period in our hospital 60 cases of childbirth without ICP as the control group,two groups have carried out surveys of maternal and neonatal outcomes,and laboratory tests.While observing the pa-tients were given drug therapy.Results All mothers were smooth delivery of the newborn,no maternal and neonatal mortality.Pro-duction of the observation group was significantly shorter than the control group gestational age,neonatal apgar 1 minute(s)and birth weight was significantly lower,cesarean section rate was significantly higher(P<0.05),two groups of postpartum hemor-rhage,amniotic fluid abnormalities,prematurity,neonatal asphyxia,hospitalization time,neonatal apgar 5 minute(s)compared with the control group had no significant difference(P> 0.05).Observation group BUN,LDH,PT,APTT,FIB levels higher,the differ-ence was statistically significant(P<0.05).Between the two groups TG,GLU levels had no significant difference(P> 0.05).blood pressure control and kidney damage and prenatal affecting intrahepatic cholestasis of pregnancy independent risk factor for the inci-dence(P<0.05).After treatment,the observation group 42 cases were cured,14 cases markedly effective,4 cases ecfectiveness and no case failure.markedly effective rate was 93.3%,the effective rate was 100.0%.Conclusion ICP for maternal and newborn have a certain influence,many accompanied by renal dysfunction,blood pressure control and kidney damage and check-ups during preg-nancy that affect the incidence of ICP independent risk factors,drug therapy can achieve better results.
