Preliminary research on the establishment of reference interval of serum pepsinogen in healthy people
10.3969/j.issn.1673-4130.2014.10.008
- VernacularTitle:建立健康者血清胃蛋白酶原参考值区间的初步研究
- Author:
Hongliang CHEN
;
Wenyou TENG
;
Hongxia YUAN
;
Lepan ZHU
;
Yangnan ZHANG
;
Changhong HUANG
;
Wei LIU
;
Guozhi DAI
- Publication Type:Journal Article
- Keywords:
pepsinogens;
reference values;
enzyme-linked immunosorbent assay;
healthy people
- From:
International Journal of Laboratory Medicine
2014;(10):1251-1252,1255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution characteristics of serum pepsinogen (PG) in healthy people and its reference interval establishment .Methods 3 753 healthy people were enrolled and divided into <45-year old ,45- <60-year old and ≥60-year old group according to their ages .Double antibody sandwich enzyme-linked immunosorbent assay was used to detect PG Ⅰ ,Ⅱ . Results Detection results of serum PG Ⅰ ,PGⅡ and PGⅠ /PGⅡ of male and female healthy people in different age group showed a skewed distribution(P<0 .05) .Serum PGⅠ and PGⅠ /PGⅡlevels of females were significantly higher than males(P<0 .01) .In the same age group ,difference of serum PGⅡ levels between males and females was not statistically significant (P>0 .05) .In the same gender ,pairwise comparison of PGⅠlevels was conducted in different age groups ,and the difference showed no statistical sig-nificance(P>0 .05) .PGⅡlevel increased with age increasing (P<0 .01) while PGⅠ /PGⅡlevel increased with age reducing (P<0 .05) .Percentile method was adopted to determine the 95% reference interval ,the bilateral reference intervals (P2 .5 - P97 .5 ) was taken for PGⅠ ,unilateral upper limit(≤ P95 ) for PGⅡ and unilateral limit (≥ P5 ) for PGⅠ /PGⅡ .Conclusion The establishment of serum PG Ⅰ ,PG Ⅱ ,PG Ⅰ /PG Ⅱ reference intervals of healthy people provides a basis for the prevention and treatment for stomach disease .
