Detection of lymphocyte subsets in peripheral blood of patients with drug eruption and its significance
10.3969/j.issn.1673-4130.2014.10.014
- VernacularTitle:药疹患者外周血淋巴细胞亚群的检测及其意义
- Author:
Fei TAN
;
Xiaohui MO
;
Jia CHEN
;
Chuguang ZHANG
;
Tingting HU
;
Fei WU
;
Ningjing SONG
;
Jun GU
- Publication Type:Journal Article
- Keywords:
drug eruptions;
lymphocytes subsets;
flow cytometry;
peripheral blood
- From:
International Journal of Laboratory Medicine
2014;(10):1266-1267,1269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of lymphocyte subsets in peripheral blood of patients with drug eruption . Methods 18 newly diagnosed patients were served as the drug eruption group ,and were subdivided into cephalosporin group (n=9) ,penicillin group(n=5) and Chinese medicine group(n=4) according to different sensitizing drugs .20 healthy people were taken as the control group .Flow cytometry were utilized to detect the percentages and absolute counts of T lymphocytes (CD3+ ,CD3+CD4+ and CD3+CD8+ ) ,B lymphocytes ,natural killer cell(NK) and natural killer T lymphocytes(NKT) in their peripheral blood . Results Differences of percentages of T lymphocytes (CD3+ ,CD3+ CD4+ ) ,B lymphocytes ,NKT cells between the drug eruption group and the control group showed statistical significant (P<0 .05) .Difference of percentages of CD3+ CD8+ lymphocytes of pa-tients between the drug eruption group and the control group demonstrated no statistical significant (P>0 .05) ,while that of abso-lute counts of T and B lymphocytes of patients was statistical significant between the drug eruption group and the control group (P<0 .05) .Conclusion The percentages of CD3+ ,CD3+CD4+ lymphocytes of patients with drug eruption decrease ,while those of NKT cells increase ,which may be related to the patients′immune regulation .
