Clinical significance of combined detection of serum NT-proBNP,cTnT and myoglobin in acute myocardial infarction diagnosis
10.3969/j.issn.1673-4130.2014.09.019
- VernacularTitle:血清N T-proBN P、cT nT 和肌红蛋白联合检测在急性心肌梗死诊断中的临床意义
- Author:
Lishu DU
;
Longyu PING
;
Manli ZHANG
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
myoglobin;
troponin T;
natriuretic peptide,brain;
diagnosis
- From:
International Journal of Laboratory Medicine
2014;(9):1134-1135,1137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of combined detection of serum cardiac troponin T (cTnT ) ,N-termi-nal pro-B-type natriuretic peptide(NT-proBNP) and myoglobin(Myo) in acute myocardial infarction diagnosis .Methods 440 pa-tients with main symptoms of acute chest pain were enrolled and divided into AMI group and non-AMI group ,and 220 healthy peo-ple were served as the control group .BECKMAN COULTER Access 2 automated chemiluminescent microparticle immunoassay analyzer was employed to detect their serum NT-proBNP ,cTnT and Myo concentrations .Results The serum concentrations of NT-proBNP ,cTnT and Myo of patients with AMI were (3 546 .12 ± 220 .95) pg/mL ,(0 .13 ± 0 .02)μg/L and (88 .12 ± 14 .27)μg/L , respectively ,which were significantly higher than those in non-AMI group and the control group(P<0 .05) .Areas under the curve (AUC) of receiver operator characteristic(ROC) of NT-proBNP ,cTnT and Myo detection were 0 .809 ,0 .851 and 0 .749 ,respec-tively ,and the ROC curve AUC of cTnT detection was markedly higher than that of Myo (P<0 .05) .The sensitivity ,specificity and diagnostic accuracy of combined detection of NT-proBNP ,cTnT and Myo were 0 .957 ,0 .950 and 0 .948 ,respectively ,which was significantly higher than those in combined detection of any two kinds of indicators (P<0 .05) .Conclusion Combined detection of serum NT-proBNP ,cTnT and Myo can improve the sensitivity ,specificity and diagnostic accuracy in AMI diagnosis .
