The study of multivoxel 1 H-MRS in detection of different hippocampal regions of Alzheimer’s disease
10.3969/j.issn.1002-1671.2014.04.003
- VernacularTitle:多体素氢质子MR波谱在阿尔兹海默病海马的分区研究
- Author:
Fei CHEN
;
Bing ZHANG
;
Yun XU
;
Xin ZHANG
;
Zhenyu YIN
;
Ming LI
;
Huiting WANG
;
Bin ZHU
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
hippocampus;
multivoxel 1 H-MRS;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2014;(4):552-556,579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the metabolic changes and the metabolites distribution of different hippocampal regions (head,body and tail)in patients with Alzheimer’s disease (AD)using 1 H-MRS for early diagnosis.Methods The hippocampal multivoxel 1H-MRS at 3.0 T was scanned in 30 patients with AD and other 30 normal cognitive elders (NC)as contrast.The data obtained were processed at a workstation.The hippocampus was divided into 3 parts (head,body and tail),and the ratios of N-acetylaspartate (NAA)/creatine (Cr),myoinositol (MI)/Cr and MI/NAA were calculated respectively.The metabolite ratios and distribution changes were compared between group AD and NC.Results Compared with the group NC,the NAA/Cr in group AD in bilateral hippocampal body and tail was decreased,whereas the MI/Cr and MI/NAA in bilateral body and tail,MI/NAA in left head were opposite (P<0.01).In group NC,the NAA/Cr was gradually decreased from the bilateral hippocampal heads to tails (P<0.01),however,the MI/NAA was opposite (P<0.01).No distribution differences in every metabolic ratios of bilateral hippocam-pus were found in AD group (P>0.05).Conclusion Metabolic changes and disappearance of the normal distribution in different hippocampal regions detected by 1 H-MRS provide helpful clues for early diagnosis of the AD.
