Clinical effect observation of angioplasty for symptomatic intracranial atherosclerotic stenosis
10.3969/j.issn.1672-5921.2014.04.003
- VernacularTitle:血管成形术治疗症状性颅内动脉粥样硬化性狭窄的临床疗效观察
- Author:
Juan DU
;
Qiankun CAI
;
Yunyun XIONG
;
Qiliang DAI
;
Lihui DUAN
;
Zhongming QIU
;
Fang YANG
;
Gelin XU
;
Guanghui CHEN
;
Xinfeng LIU
;
Qin YIN
- Publication Type:Journal Article
- Keywords:
Intracranial atherosclerosis;
Endovascular intervention;
Prognosis;
In-stent restenosis
- From:
Chinese Journal of Cerebrovascular Diseases
2014;(4):178-182,191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of angioplasty for symptomatic intracranial atherosclerotic stenosis. Methods Eighty-two patients with symptomatic intracranial atherosclerotic stenosis whom underwent angioplasty after the failure of standard medical therapy were enrolled from Nan-jing Stroke Registry Program from September 2010 to June 2013.Nine of them underwent routine balloon angioplasty alone and 73 underwent intracranial stenting.The median time from onset to surgery was 24.5 days.The occurrence of endpoint events (any stroke ≤30 d after procedure,death and ischemic stroke >30 d in guilty vessels or original stenosis had restenosis and needed to be treated again)was assessed. The incidence of restenosis was followed up with imaging (CTA or DSA). Results (1)In the 82 patients, the success rate of operation was 92.7%(n=72 ),and 78 (95.1%)received follow-up,4 were lost to follow-up.The median follow-up time was 22.5 months (range 9 to 29 months ).Ten patients had an endpoint event,7 of them were ischemic stroke,1 was cerebral hemorrhage,and two were severe asymptomatic restenosis who underwent stenting again.The endpoint events of 3 patients occurred at day 30 after procedure (at ≤24 h after procedure).Kaplan-Meier curves showed that the incidences of cumulative endpoint events at 1,6,12,and 24 months were 3.7%,8.6%,11%,and 13%,respectively.(2)60 patients (73.2%)received imaging examination (11 CTA and 49 DSA ).Restenosis occurred in 17 patients (28.3%),among them the incidence of symptomatic restenosis was 5%(n =3 ),and asymptomatic restenosis was 23.3%(n=14). Conclusion After a comprehensive assessment and a rigorous screening, the safety is high and the mid- and long-term efficacy are satisfactory in patients with symptomatic intracranial arterial stenosis who are treated with angioplasty when their medical treatment is invalid.
